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KMID : 0370220110550030213
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Yakhak Hoeji
2011 Volume.55 No. 3 p.213 ~ p.218
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The Sedative Effects of Ethanol Extract from Cimicifugae Rhizoma
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Choi Yun-Jung
Yoon Seo-Young
Choi Ji-Young
Woo Tae-Seon
Son Kun-Ho
Lee Yong-Soo
Cheong Jae-Hoon
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Abstract
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The aim of this study is to evaluate the sedative effects of ethanol extract and the three major constituents of Cimicifugae Rhizoma. They decreased locomotor activity significantly, and enhanced sleeping duration induced by thiopental sodium. The ethanol extract of Cimicifugae rhizoma and 24-epi-7,8-didehydrocimigenol-3-xyloside (24-epi.) increased the Cl- influx into the intracellular area of SH-SY5Y neuroblastoma cells significantly. The present results demonstrate that the sedative effects of Cimicifugae rhizoma are mediated via the GABA-gated Cl- channel, partly by 24-epi.
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KEYWORD
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Cimicifugae Rhizoma, sedative effect, Cl- influx, GABA receptor, triterpenoids
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